Numerous studies have reported that gut microbial homeostasis plays an essential part in maintaining human health (Gentile & Weir, 2018 Lynch & Pedersen, 2016). The gut microbiome is composed of bacteria, eukaryotic viruses, bacterial viruses (bacteriophages), fungi, and archaea. Accompanied by a broad influence on the general physiology of the gastrointestinal tract, the aging process also inevitably affects gut microbes in human beings (Biagi et al., 2010) or non-human primates (Duan et al., 2019). For example, previous studies have shown that aging is implicated in the development of atherosclerosis (Wang & Bennett, 2012), Alzheimer's disease (Qiu et al., 2009), and innate immune dysregulation (Shaw et al., 2013). Our gut virome analysis provides new insight into how aging influences the gut virome of non-human primates.Īging often negatively impacts the vitality and health of human beings. Furthermore, the age-related DNA gut viral functions were enriched for genetic information processing, nucleotide, and folate metabolism. Additionally, the co-occurrence analysis revealed that the age-related bacteriophages were correlated in an extensive and complex manner with the main intestinal bacteria (i.e., Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria phyla). The gut viruses were dominated by bacteriophages, the most abundant of which was the Caudovirales order (i.e., Siphoviridae, Myoviridae, and Podoviridae families). We found that the DNA gut virome from these monkeys differed substantially among the three groups.
Here, we compared the DNA gut viral composition of 16 female cynomolgus monkeys ( Macaca fascicularis) at three life stages (young, adult, and old) using the shotgun metagenome sequencing method.
Emerging evidence indicates that aging may affect the gut bacteriome in cynomolgus macaques, but little is known about whether or how the gut virome changes with age. Aging is a critical factor affecting physical health and disease in mammals.
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